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愤世嫉俗的年轻商人克劳迪欧（亚历山德罗·罗亚 饰）赶着要和客户进行重要会议，却受困在罗马办公室的电梯中，随即演变成一场不可收拾的梦魇。在电梯之外，某种致命病毒正在大肆扩散，受到传染者将变成极端狂暴的活死人。克劳迪欧必须千方百计想逃出电梯，然而，这部与世隔绝的电梯似乎已变成全市最安全的地方……

　　Special Agent Alexander Connor is sent to investigate a house, from which a woman named Sandra has made numerous 911 calls. Things become more complicated than expected for Agent Connor, as he finds he must also rescue a police officer who responded to the home 24 hours earlier. Soon, Agent Connor will discover a horrifying secret; that Sandra is one of LUMEN CORPORATION's donors and has devoted her house to the corporation; a house which has been turned into a research lab for atrocious experiments performed on human beings.

　　

Haunted by the death of his father and other psychological traumas, Daniel (Roberto Scorza) returns to the home where he was raised. Faced with intense emotional scars, as well as physical -- which are realized by the years of self-harm depicted by the cuttings adorning his body -- he enters the bathroom to begin a journey of self-exploration, self-mutilation and quite possibly...